By T. Hugh Jones
Testosterone has a tremendous effect on significant organ platforms and tissues, together with mind, metabolism, cardiovascular in addition to musculoskeletal and immune platforms. masking many medical components, this publication will pay specific recognition to the prognosis and administration of hypogonadism, discussing present instructions, biochemical overview, new suggestions in testosterone alternative remedy and long term tracking of handled males. moreover the function of testosterone deficiency in getting older, weight problems, muscle functionality and frailty and erectile disorder is covered.Recent facts for the function of testosterone within the pathogenesis of power illnesses similar to diabetes, heart problems and osteoporosis is mentioned. New advancements within the capability remedy of those scientific stipulations also are. awarded. basically of curiosity to endocrinologists, urologists, andrologists and sexologists, the diversity of issues lined can also be appropriate to basic care physicians, gerontologists, diabetologists and cardiologists.
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Extra info for Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37)
Therefore, in principle, the toxicology of TU is the same as for other cleavable testosterone fatty acid esters such testosterone propionate, testosterone enanthate or testosterone cypionate. TU as an oral preparation has been available for more than 30 years. It is well-tolerated, but the bioavailability of testosterone leaves much to be desired. It requires careful dosing at least 2 times a day and it must be taken with fatty meals in order to achieve acceptable plasma testosterone levels .
Clin Chem 2005;51:1472–1479. 6 Kushmir MM, Rockwood AL, Roberts WL, Pattison EG, Bunker AM, Fitzgerald RL, Meikle AW: Performance characteristics of a novel tandem mass spectrometry assay for serum testosterone. Clin Chem 2006;52:120–128. 7 Sikaris K, McLachlan RI, Kazlauskas R, de Krester D, Holden CA, Handelsman DJ: Reproductive hormone reference intervals for healthy fertile young men: evaluation of automated platform assays. J Clin Endocrinol Metab 2005;90:5928–5936. 8 Hsing AW, Stanczyk FZ, Belanger A, Schroeder P, Chang L, Falk RT, Fears TR: Reproducibility of serum sex steroid assays in men by RIA and mass spectrometry.
Androgen Replacement with DHT The effects of testosterone are mediated directly as testosterone or after conversion to either DHT or estradiol locally in target tissues. The reduction of testosterone to DHT is an amplification mechanism of the androgenizing effects of testosterone. DHT binds to the same receptor as testosterone but its receptor binding is stronger resulting in a considerably higher biopotency than testosterone itself. DHT, as opposed to testosterone, cannot be aromatized to estradiol and acts, therefore, as a pure androgen.